Abstract: Objective To study percutaneous intervention and simple drug therapy of angina pectoris after coronary artery bypass grafting(CABG).Methods All 262 cases with angina pectoris after CABG were divided into percutaneous transluminal coronary intervention(PCI)group(n =129) and simple drug therapy group(drug group)(n =133).The incidence of major adverse cardiovascular events(MACE),revascularization of non-target vessels,cardic function and eardie readmission rate after 1 year were followed up.Results Of 262 patients with angina pectoris after CABG,245 cases were followed up successfully,and 124 cases were in PCI group,the other 121 cases were in drug group.The incidence rate of MACE in PCI group[9.7%(12/124) ] was higher than that in drug group [ 23.1%(28/121)](P < 0.05).Rate of angina reocurrence in PCI group and drug group was 14.5%(18/124) and 27.3%(33/121)(P < 0.01).Rate of readmission for cardiac events in PCI group and drug group was 10.5%(13/124) and 21.5 %(26/121)(P < 0.01).Left ventricular ejection fraction in PCI group was higher than that in drug group[(64±l 1)% vs(58±8)%,P <0.05 ].Conclusion Percutaneous intervention is effective and safe for the patients with angina pectoris post-CABG and can improve clinical prognosis.