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The disability in patients with schizophrenia treated with chlorpromazine and risperidone

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Author:
LI He-jun(Department of Medical Services, Fifth Hospital of Tangshan,Hebei Province, Tangshan 063004, China)
YANG Jie(Department of Medical Services, Fifth Hospital of Tangshan,Hebei Province, Tangshan 063004, China)
Journal Title:
China Medicine
Issue:
Volume 07, Issue 06, 2012
DOI:
10.3760/cma.j.issn.1673-4777.2012.06.031
Key Word:
Risperidone;Chlorpromazine;Disability;Schizophrenia

Abstract: Objective To explore the disability in patients treated with schizophrenia with using respectively chlorpromazine and risperidone.Methods Two hundred outpatients or hospitalization patients with schizophrenia were randomly divided into chlorpromazine group( 100 cases) and risperidone group( 100 cases) ; the degree of disability by WHO disability assessment scale Ⅱ (WHO-DAS Ⅱ ),social disability screening schedule(SDSS),WHO quality of life(WHOQOL) at the time of half a year,one year and two years were ananlyzed.Results The scores of risperidone group in all scales were significantly higher in chlorpromazine group in each period ( P < 0.05 or P <0.001 ).The validity of consistency and correlation was high in all scales.Conclusion Risperidone is significantly better than chlorpromazine in terms of reducing the rate of disability,improving the social function and reducing the degree of disability.

  • [1]王善澄.实用康复精神医学.长沙:湖南科学技术出版社,1997:28-29.
  • [2]Bums T,Patrick D.Social functioning as an outcome measure in schizophrenia studies.Acta Psychiatr Scand,2007,116 (6):403-418.
  • [3]张明园.精神科评定量表手册.2版.长沙:湖南科学技术出版社,1998:163-165.
  • [4]刘美娜,杨镇,李永泉,等.精神分裂症患者的健康生命损失研究.中国公共卫生,2006,22(12):1473-1474.
  • [5]Ayuso-Gutiérrez JL,del Rio Vega J M.Factors influencing relapse in the long-term course of schizophrenia.Schizophr Res,1997,28 (2-3):199-206.
  • [6]何磊英,陈峥.非典型抗精神病药物用于精神分裂症长程治疗的研究进展.世界临床药物,2010,31(7):438-442.
  • [7]沈渔邨.精神病学.4版.北京:人民卫生出版社,2001:394-398.
  • [8]Bilder RM,Goldman RS,Volavka J,et al.Neurocognitive effects of clozapine,olanzapine,risperidone,and haloperidol in patients withchronic schizophrenia or schizoaffective disorder.Am J Psychiatry,2002,159(6):1018-1028.
  • [9]Stip E,Lussier I.The effect of risperidone on cognition in patients with schizophrenia.Can J Psychiatry,1996,41 (8 Suppl 2):S35-S40.
  • [10]赵琦,叶伟兵.抗精神病药物的现代研究进展.亚太传统医药,2010,6(9):152-153.
  • [11]张淑芬,潘继英,全传升.喹硫平与利培酮治疗女性首发精神分裂症疗效比较.中国基层医药,2010,17 (21):2943-2945.
  • [12]张超,祈明,盛海涛.奥氨平与齐拉西酮治疗精神分裂症对照研究.实用药物与临床,2010,13(6):414-415.
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