Abstract： Objective To explore the relationship between insulin resistance( IR),the level of inflammation factors and severity of coronary artery lesion in non-diabetic patients with coronary heart disease ( CHD ).Methods Totally consecutive 136 non-diabetic patients received coronary angiography were enrolled and divided into four groups according to the number of diseased vessels:control group(36 patients),one vessel diseased group (36 patients),two vessel diseased group(34 patients)and three vessel diseased group(30 patients).The level of fasting plasma glucose,fasting insulin,blood lipids,tumor necrosis factor-alpha(TNF-α) and hypersensitive C-reactive protein(hs-CRP) were analyzed respectively.Homeostasis model assessment index was used for quantitative analysis of insulin resistance index(IRI).Gensini's score was used for evaluation of severity of coronary artery lesion.Results The level of IRI,TNF-α and hs-CRP in CHD groups were significantly higer than those in the control group( P ＜ 0.01 ).In CHD groups,with the number of the coronary artery disease increasing,the level of IRI,TNF-α,hs-CRPand Gensini's score were becoming higher and higher( P ＜ 0.05 ).Gensini's score presented increasing trend [ (44.4 ± 22.7 ) vs (27.5 ± 19.2),(70.7 ± 25.4 ) vs (44.4 ± 22.7 ) scores,P ＜ 0.05 ].Correlation analysis showed that Gensini's score was positively correlated with the level of IRI,TNF-α and hs-CRP(r =0.382,0.357,0.443,P ＜ 0.05).Multivariate linear regression model showed that age,IRI,TNF-αt and hs-CRP were independent facters of Gensini's score.Conclusion IR and inflammatory activity are found in non-diabetic patients with CHD.The levels of IRI,TNF-α and hs-CRP are closely correlated with the severity of coronary artery stenosis in non-diabetic patients with CHD.