Abstract： Objective To observe the effect of amlodipine/atorvastatin on perioperative blood pressure in hypertensive patients during non-cardiac surgery.Methods Totally 80 patients with hypertension were divided into two groups,a ged 40-75 years old,in May-July 2011 when they are in bone surgery,general surgery and urology surgery.There were 40 cases in the amlodipine/atorvastatin calcium treatment group and 40 cases in the nifedipine control group.Morning blood pressure in the day of surgery,averge blood pressure,angina pectoris,acute myocardial infarction,acute left heart failure,transient ischemic attack,cerebral infarction,cerebral hemorrhage and incidence of adverse events in the two groups were observed and compared.Results Morning blood pressure in the day of surgery and perioperative average blood pressure in the treatment group were significantly lower than those in the control group.There were one case of angina and one case of transient ischemic attack in treatment group; there were one case of angina,one case of left ventricular failure,one case of transient ischemic attack and one case of cerebral infarction in the control group.Cardiovascular and cerebrovascular adverse events in both groups were significantly different.Conclusion Amlodipine/atorvastatin in hypertensive patients with non-cardiac surgery can control perioperative blood pressure stably and safely.