Abstract： Objective To investigate the effects of radiation pneumonitis in different cisplatin-based concurrent chemotherapy regimens and three-dimensional conformal radiation therapy (3D-CRT)for locally advanced non-small cell lung cancer(NSCLC).Methods A retrospective analysis of 120 cases with locally advanced nonsmall cell lung cancer was conducted.All patients were treated with cisplatin-based concurrent chemotherapy and three-dimensional conformal radiation therapy and randomly divided into EP( etoposide + cisplatin)regimen group (57 cases),NC( vinorelbine + cisplatin) regimen group(41 cases) and DC( docetaxel + cisplatin) regimen group(22 cases).The occurrence,prognosis and influencing factors of radiation pneumonitis were observed.Results The incidence of 1 and 2 grade radiation pneumonitis was 33.3％ ( 19/57 )in EP regimen group,29.3％ ( 12/41 )in NC regimen group and 22.7％ (5/22) in DC regimen group.3 and 4 grade radioactive pneumonia was 10.5％ (6/57),9.7％ (4/41),4.5％ ( 1/22 ) respectively.The differences of levels of radiation pneumonitis in three group were not statistically significant( P ＞ 0.05 ).Conclusions The radiation pneumonitis in cisplatin-based concurrent chemotherapy and three-dimensional conformal radiation therapy for locally advanced NSCLC are tolerable.The differences of cisplatin plus docetaxel,etoposide or vinorelbine combination chemotherapy are not statistically significant.Docetaxel is more sensitive to radiation than to etoposide and vinorelbine.It is suggested that old patients with chronic bronchitis should first have 3DCRT combined with DC chemotherapy.