Abstract: Objective To observe the effect of salmeterol and propionic acid fluticasone combined with thiazide torsten bromine ammonium dry inhaler on BODE index of moderate to severe stabilization chronic obstructive pulmonary disease(COPD).Methods Forty-seven cases of severe stabilization COPD patients were randomly divided into two groups:treatment group and control group.The treatment group was given inhaled thiazide torsten bromine ammonium dry inhaler and salmeterol and propionic acid fluticasone; the control group was given inhaled thiaside bromide dry powder,respectively.BODE index betore treatment,two weeks,four weeks and eight weeks after treatment was determined.Results After treatment of eight weeks,the BODE index and Modified Medical Research Council Scale ( MMRC ) had significant difference between treatment group and control group [( 3.0 ± 2.1 ) vs (3.5 ± 2.4),( 1.8 ± 0.7 ) scores vs ( 2.0 ± 0.8 ) scores,P < 0.05].Conclusion Salmeterol and propionic acid fluticasone combined with thiazide torsten bromine ammonium dry inhaler can significantly improve the quality of life in patients with moderate stable chronic obstructive pulmonary disease and has low side effects.