Abstract: Objective To observe the angiographic characteristics of coronary lesions in patients with coronary disease and impaired glucose regulation (IGR).Methods Coronary angiography was performed in 488 cardiovascular disease(CAD) patients.Capillary blood glucose was analyzed before and 2 h after an oral glucose tolerance test.Associations between fasting blood glucose as well as 2 h-BG levels and the risks for CAD were assessed by logistic regression analysis. Results One hundred and four patients were diagnosed of impaired fasting glucose (IFG),87 patients were diagnosed of impaired glucose tolerance( IGT),174 patients were diagnosed of type 2 Diabetes mellitus( 2DM ) and 123 patients were diagnosed of normal blood glucose(NGT).There were significant differences in the number of diffuse lesion vessels among IFG,IGT,2DM and NGT( 1.36,1.47,1.52 vs 0.70)( P <0.05).By means of logistic regression analysis,C-reactive protein and HbA1c were found to be the independent risk factors of diffused vascular lesions.Conclusion IGR can cause diffused vessel lesions.