Abstract： Objective To observe and assess the psychological disorders such as anxiety and depression in arrhythmic patients without organic heart disease as well as clinical efficacy and the quality of life with pharmacotherapy using antidepressants.Methods Two hundred and twelve patients with premature beats but without organic heart disease were randomly assigned to the observation group and control group with 106 patients in each group.All the patients were given with metoprolol and fluxetine or deanxit and metoprolol separately.The clinical signs、electrocardiograph( ECG),dynamic electrocardiogram( DCG),self-rating anxiety scale (SAS) and Self - rating Depression Scale (SDS) score were observed before treatment and 2 months after treatment.The Evaluation of Chinese questionnaire of quality of life in patients with cardiovascular disease was adopted to evaluate patients' quality of life.Results Compared to pre -treatment,the observation group's SAS,SDS score decreased significantly[ SAS:(39 ±9) vs (52 ± 10) ;SDS:(39 ± 10) vs (58 ± 11) ;P ＜ 0.01 ],however there were no significant changes in control group (P ＞0.05).Compared with control group,the observation group's SAS,SDS score decreased significantly [ SAS:(39 ±9) vs (53 ± 10) ;SDS:(39 ± 10) vs (58 ±9) ; P ＜0.01 ].The clinical improvement rate of observation group's symptoms regarding chest pain、thorax suffocation and breath hard were respectively 84.9％,95.9％,96.4％ and 92.1％,which were significantly higher than control group's 30.2％,42.6％,46.0％ and 48.6％( P ＜ 0.01 ).The effective rate of observation group's premature beats was 84.0％ ( 89/106),which was also significantly higher than control group's 53.8％ (57/106).The observation group's score of Evaluation of Chinese questionnaire of quality of life in patients with cardiovascular disease were significantly higher than that of control group (P ＜ 0.01 ).Conclusions The patients with premature beats who suffer from sustained cardiovascular symptom are often accompanied by psychological disorders of anxiety and depression.The quality of life in patients with premature beats with anxiety and depression can also be improved.