Abstract： Objective To detect the effects of different doses of rosuvastatin on heart function of patients with acute myocardial infarction recanalisated after intravenous thrombolysis,and to evaluate the clincal effect and safety.Methods Seventy-six patients with acute myocardial infarction who treated with intravenous thrombolysis were divided into two groups.Based on routine treatment,the patients were given rosuvastatin 10mg/d (routine dose group) and 40mg/d (high dose group) respectively within 24h of the disease onset.The LVEF and LVFS were detected at the end of 1,4 and 12 weeks after treatment,and the 6-MWT were detected at the end of 4 and 12 weeks after treatment.Results The LVEF,LVFS and 6-MWT in high dose group at the end of 12 weeks after treatment were all higher than that in routine group[ (51 ±10)％ vs(40 ±10)％,(29 ±8)％ vs(24 ±6)％,(313 ±90) m vs (242 ± 74) m,all P ＜ 0.05 ],There were only a minority of patients showing mild adverse reactions.Conclusion Based on routine treatment,the acute myocardial infarction patients with intravenous thrombolysis receive high dose of rosuvastatin (40 mg/d),may improve heart function and is better than that of normal dose treatment,and the safety is good,which made this treatment is worth clinical promotion.