Abstract: Objective To analyze the clinical characteristics and complications of acute coronary syndrome (ACS) in women.Methods Clinical characteristics and complications of 313 women and 857 men diagnosed of ACS in GRACE Study were observed.Results Women with ACS were older than men.The women's morbidity was significantly higher than that of men older than sixty[ 83.6% (395/472) vs 70.2% (896/1277) ].It takes longer time from onset to see a doctor in female patient with ACS than in male patient with ACS[ (131 ± 35 )h vs (114 ± 36) h ],and the duration of hospital stay in female patient with ACS is longer than that in male patient with ACS [ ( 13 ±3)d vs ( 12 ±4)d] (P <0.05).Women with ACS had more risk factors than men.Diabetes[ 36.7% ( 173/ 472)vs 22.1%(283/1277)] and Hypertension[72.5% (342/472) vs 60.9% (778/1277)] were more important for women than for men ( P < 0.05 ).The number of women diagnosed of unstable angina pectoris was more than that of men[ 50.0% (236/472) vs 37.4% (478/1277) ],while the number of women diagnosed of acute myocardial infarction was less than that of men[42.4% (200/472) vs 58.1% (742/1277) ].Less female patients had percutaneous coronary intervention ( PCI ) [ 50.2% ( 237/472 ) vs 63.8% ( 825/1277 ) ] and coronary artery bypass graft (CABG) ( P < 0.05 ) [ 1.3 % (6/472) vs 3.9% (49/1277 ) ].Conclusions Female patients with ACS have more complications and worse prognosis than male patients with ACS.