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Clinical effect of heart-protecting musk pill on silent myocardial ischemia in patients undergoing maintenance hemodialysis

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Author:
No author available
Journal Title:
China Medicine
Issue:
1
DOI:
10.3760/cma.j.issn.1673-4777.2012.01.003
Key Word:
麝香保心丸;无症状心肌缺血;维持性血液透析;炎症;Heart-protecting musk pill;Silent myocardial ischsmia;Maintenance Hemodialysis;Inflammation

Abstract: Objective To investigate the clinical effect of heart-protecting musk pill (HMP) on silent myocardial ischemia (SMI) in maintenance hemodialysis patients.Methods Seventy-eight maintenance hemodialysis patients with SMI were randomly divided into HMP group (n =40; reated with HMP) and control group (n =38;treated with aspirin,metoprolol,valsartan,amlodipine besylate and fluvastatin).The therapeutic course was two months.The serum level of Blood urea nitrogen ( BUN ),creatinine ( CRE ),glucose (GLU),total cholesterol (TC),triglyceride( TG),high density lipoprotein cholesterol( HDL-C),low density lipoprotein( LDL-C),high sensitive C reactive protein(hs-CRP),interleukin 6(IL-6) and red-cell count and hemoglobin were detected before and after treatment.The changes of SMI were observed by dynamic electrocardiogram.Results ①After therapy,the level of hs-CRP and IL-6 decreased markedly in HMP group and control group[ (4.7 ± 1.5)mg/L vs (9.7 ±4.2)mg/L,( 5.7 ± 1.5 ) mg/L vs ( 9.8 ± 4.4) mg/L; ( 53 ± 24) ng/L vs ( 88 ± 28 ) ng/L,( 67 ± 26 ) ng/L vs ( 89 ± 27 ) ng/L,P<0.01 ],but it decreased more significantly in HMP group than in routine groups( P < 0.01 ).②Frequency and lasted time of SMI were decreased significantly in two groups (P < 0.01 ) after treatment,but it decreased more significantly in HMP group ( P <0.01 ).③ Systole blood pressure were decreased significantly after treatment in two groups ( P < 0.05 ).The level of TC,TG,LDL-C,HDL-C,BUN,CRE,FPG,red-cell count and hemoglobin were not significant different between two groups before and after treatment ( P > 0.05 ).Conclusion HMP improves SMI in maintenance hemodialysis patients and the mechanism may be associated with the suppression of inflammatory response.

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