Abstract： Objective To investigate the effect of percutaneous coronary intervention (PCI) on left ventricular function of patients with ischemic cardiomyopathy. Methods The 65 patients with ischemic cardiomyopathy were divided into PCI group(32 cases) and medicine group(33 cases). PCI group accepted PCI and medicine, medicine group accepted medicine only. They were followed up for one year. Transthoracic eahocardiography (TTE) in sixth and twelfth months were examined. The LVEDV, LVEF and cardiovascular events in one year between two groups were compared. Results The improvement of left ventricular function in PCI group was better than that in medicine group. [LVEF:sixth month after treatment(38.0±2.4)% vs (36.0±2.8)%,twelfth month(43.0± 2.1)% vs (40.0±2.5)%,P＜0.05]The incidence rates of the events of acute myocardial infarction,acute left heart failure, cardiac death, rehospitalization due to cardiac insufficiency or severe myocardiac ischemic in PCI group were lower than those in medicine group in one year[6.2% vs 24.2% ,9.4% vs 30. 3% ,3.1% vs 18.2% ,18.7% vs 54.5% ,P＜0.05]. Conclusions It is effective to treat the ischemic cardiomyopathy with PCI. The PCI combined with medicine is superior to medicine only in improving left ventricular function and decreasing cardiovascular events in ischemic cardiomyopathy.