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A clinical study of recombinant human brain natriuretic peptide in patients with acute decompensated heart failure

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Author:
No author available
Journal Title:
CHINA MEDICINE
Issue:
7
DOI:
10.3760/cma.j.issn.1673-4777.2011.07.005
Key Word:
急性失代偿性心力衰竭;重组人脑利钠肽;药物治疗;Acute decompensated heart failure;Recombinant human brain natriuretie peptide;Medical treatment

Abstract: Objective To observe the efficacy and safety of intravenous infusion recombinant human brain natriuretic peptide(rhBNP)in patients with acute decompensated heart failure.Methods A total of 112 patients who suffered from acute decompensated heart failure patients were randomized into rhBNP group and control group.The rhBNP group received continuous intravenous infusion of rhBNP for 48 hours.All the patients were treated with concomitant medical therapy in accordance to AHA/ACC heart failure guidelines.Observed the change of the symptoms of physical condition and the hemodynamic parameters were observed.Results Dyspnea improvements were more significant in rhBNP group than in control group(P<0.05).Initially the NT-proBNP values increased but started to decrease in rhBNP group 2 days after withdrawal:24 h after treatment the NT-proBNP values significantly increased(P<0.05),whereas 2 hours after withdrawal of rhBNP,the NT-proBNP values decreased in the rhBNP group.And the NT-proBNP values in the control group were significantly higher than in rhBNP group(P<0.05).Pulmonary capillary wedge pressure(PCWP),right atrial pressure(RAP)and pulmonary artery pressure(PAP)de-creased in both rhBNP group and control group,and the NT-proBNP values in rhBNP group decreased to a larger extent as compared to the control group(P<0.05).seven patients in rhBNP group had hypotension.Conclusion In-travenous injection of rhBNP can significantly reduce the NT-proBNP level and improve hemodynamic parameters and clinical symptoms.

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