Abstract： Objective To observe the event-related potential(ERP P300) and learning status of epileptic children, in order to provide the experimental basis for clinic intervention. Methods ERP P300 and the pupil rating scale revised screening for learning disabilities (PRS) were done separately in 85 children with epilepsy. Also compare the statistic data between the two groups. Results The latency of ERP P300 in children with epilepsy showed significantly longer than that in the controls (P < 0.01). The total score, the verbal score and the nonverbal score of PRS in children with epilepsy showed significantly lower than those in the controls ( P < 0. 01). The ERP P300 latency, the total score and the nonverbal score of epileptic children with epileptiform electroencephalographic discharges showed significant difference from those in children without epileptiform discharge ( P < 0. 05 ). Conclusions The latency of ERP P300 is significantly delayed and the amplitude of ERP P300 is significantly decreased in children with epilepsy. The condition of damage of their cognitive and learning fuction and the abnormal degree of their ERP P300 is closely related to epitiform discharges.