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Effect of bisoprolol on heart rate turbulence and malignant ventricular arrhythmia in patients with dilated cardiomyopathy

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Author:
MA Jian-lin(Department of Cardiology,Hainan Provincial People's Hospital,Haikou 570311,China)
LIN Jin(Department of Cardiology,Hainan Provincial People's Hospital,Haikou 570311,China)
SU Zhe-tan(Department of Cardiology,Hainan Provincial People's Hospital,Haikou 570311,China)
ZHANG Jing-wen(Department of Cardiology,Hainan Provincial People's Hospital,Haikou 570311,China)
Journal Title:
CHINA MEDICINE
Issue:
Volume 06, Issue 04, 2011
DOI:
10.3760/cma.j.issn.1673-4777.2011.04.001
Key Word:
Cardiomyopathy;dilated;Bisoprolol;Heart rate turbulence;Arrhythmia

Abstract: Objective To observe the effect of bisoprolol on heart rate turbulence (HRT) and malignant ventricular arrhythmia(MVA) in patients with dilated cardiomyopathy (DCM). Methods Forty-five DCM patients with premature ventricular beats were chosen as treatment group, and 20 cases were enrolled as control group. Both groups were given with bisoprolol or placebo for 28 days. All patients were examined with ambulatory electrocardiogram monitoring for twenty-four hours before and after bisoprolol or placebo was administered for 28 days. The number of patients with MVA, turbulence onset (TO) and turbulence slope (TS) were analyzed. Results After bisoprolol was administered for 28 days in patients with DCM, the number of patients with MVA decreased by 17.8%.TO decreased, and TS increased. Conclusion Bisoprolol can reduce the incidence of MVA and improve HRT in patients with DCM.

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