Abstract： Objective To observe the effect of bisoprolol on heart rate turbulence (HRT) and malignant ventricular arrhythmia(MVA) in patients with dilated cardiomyopathy (DCM). Methods Forty-five DCM patients with premature ventricular beats were chosen as treatment group, and 20 cases were enrolled as control group. Both groups were given with bisoprolol or placebo for 28 days. All patients were examined with ambulatory electrocardiogram monitoring for twenty-four hours before and after bisoprolol or placebo was administered for 28 days. The number of patients with MVA, turbulence onset (TO) and turbulence slope (TS) were analyzed. Results After bisoprolol was administered for 28 days in patients with DCM, the number of patients with MVA decreased by 17.8%.TO decreased, and TS increased. Conclusion Bisoprolol can reduce the incidence of MVA and improve HRT in patients with DCM.