Abstract： Objective To evaluate the method and therapeutic effect with reconstruction of giant chest wall defect using associated autologous-tissue with artificial prosthesis. Methods To retrospectively analyze clinical data of 15 patients with giant chest wall defect ( including 9 cases with thoracic injury and 6 cases with chest wall tumor resection), all patients had performed skeletal reconstruction of chest wall and associated autologoustisse with artificial prosthesis. Results The postoperative recovery of all patients were good and healing well, their intrathoracic drain tube were pulled out in 5 days after operation and their average stay were (15.7 ± 3.4) days. Although 4 cases had been complicated by respiratory distress syndrome and performed adjunctive therapy with breathing machine for 5 days, the four patients had good postoperative recovery. The mean follow-up period was (9.3 ±0.7) months (from 6 to 12 months ) and all patients had successfully restored the stability of chest without death or severe complication. Conclusion Using associated autologous-tissue with artificial prosthesis to treat chest wall giant defect is a convenient and simple method, which shows well therapeutic effects and promising application.