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The influence of subclinical hypothyroidism on C-reactive protein and microalbuminuria in patients with coronary heart disease

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Author:
TU Yan-ping(Department of Geratology, People's Hospital of Jiangxi Province, Nanchang 330006, China)
LEI Meng-jue(Department of Geratology, People's Hospital of Jiangxi Province, Nanchang 330006, China)
WU Xiao-he(Department of Geratology, People's Hospital of Jiangxi Province, Nanchang 330006, China)
GONG Ai-bin(Department of Geratology, People's Hospital of Jiangxi Province, Nanchang 330006, China)
WEI Wei-rong(Department of Geratology, People's Hospital of Jiangxi Province, Nanchang 330006, China)
WANG Ling-ling(Department of Geratology, People's Hospital of Jiangxi Province, Nanchang 330006, China)
AI Wen-wei(Department of Geratology, People's Hospital of Jiangxi Province, Nanchang 330006, China)
WU Su(Department of Geratology, People's Hospital of Jiangxi Province, Nanchang 330006, China)
YAO Xiao-lu(Department of Geratology, People's Hospital of Jiangxi Province, Nanchang 330006, China)
Journal Title:
CHINA MEDICINE
Issue:
Volume 06, Issue 03, 2011
DOI:
10.3760/cma.j.issn.1673-4777.2011.03.003
Key Word:
Subclinical hypothyroidism;Coronary disease;C-reactive protein

Abstract: Objective To observe the influence of subclinical hypothyroidism on c-reactive protein (CRP) and microalbuminuria (MAU) in patients with coronary heart disease. Methods The level of serum triglyceride ( TG), total cholesterol( TC), homocysteine (Hcy), CRP and urinary MAU was measured in 80 patients with coronary heart disease (of them 40 complicated with subclinical hypothyroidism). Results The levels of TG, TC,CRP, and MAU increased significantly in the patients complicated with subclinical hypothyroidism as compared with those without subclinical hypothyroidism ([(1.7±0.8)mmol/L vs (1.5±0.5)mmol/L, ( 5.7 ± 0.8 ) mmol/L vs (4.5 ±0.7)mol/L, (4.8 ± 1.6)mg/L vs (3.1 ± 1.3)mg/L, (51.2 ±3.5)mg/L vs (42.4±4.7)mg/L]P<0.01 or P<0.05). Conclusions Subclinical hypothyroidism can not only affect lipid metabolism, but also increase inflammation and microalbuminuria in patients with coronary heart disease.

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