Abstract: Objective To investigate the results of evidence-based medicine on use of aspirin, beta blockers, statin, angiotensin-converting enzyme inhibitors (ACEIs) /angiotensin receptor blockers (ARBs) in hospitalized patients with ST-segment elevation (STEMI) during 15 years. Methods Selected four groups of patients with acute myocardial infarction admitted to cardiology department of Xuanwu hospital between January 1994 and December 2009:1994. 1-1995.12 (group A), 1999. 1-2000. 12 (group B), 2004. 1 2005. 12-(group C), 2009. 12( group D). A total of 879 patients with STEMI whose emergency time within 24 hours were retrospectively analyzed. Results The utilization rate of aspirin in STEMI patients remained more than 97%, the highest utilization among four kinds of medicine. The in-hospital utilization rates of Beta blockers, statins, ACEI/ARB rose significantly: from 7.2%, 25.3%, 37.9% to 93.2%, 90.2%, 95.5% respectively during 15 years. Conclusion With the development of evidence-based medicine, the used status of aspirin, beta blockers, statins, ACEI/ARB in STEMI patients haveconsolidated in recently 15 years.