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Co-expression and clinical significance of multi-drug resistance factors in lung cancer

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Author:
WANG Chun(Department of Respiratory, People's Hospital of Liaoning Province, Shen yang 110016, China)
ZHANG Xiao-yu(Department of Respiratory, People's Hospital of Liaoning Province, Shen yang 110016, China)
HUANG Jian-ning(Department of Respiratory, People's Hospital of Liaoning Province, Shen yang 110016, China)
XIAO Ming-ming()
JING Shi-bing()
Journal Title:
CHINA MEDICINE
Issue:
Volume 06, Issue 01, 2011
DOI:
10.3760/cma.j.issn.1673-4777.2011.01.020
Key Word:
Lung neoplasms;Multi-drug resistance-associated proteins;Immunohistochemistry method

Abstract: Objective To study the expression,co-expression, and clinical significance of four multi-drug resistance factors in lung cancer. Methods The P-glycoprotein (P-gp), mullidrug resistance-associated protein ( MRP, lung resistance protein ( LRP), glutathione-S-transferase (GST-π) of 60 lung cancer patients were detected by immunohistochemical methods. Results The positive drug resistance rate of P-gp, MRP, LRP, GST-π was 53.3% (32/60) ,63.3% (38/60) ,70.0% (42/60) ,80.0% (48/60) respectively. Patients with NSCLC had significantly higher expression of the drug resistance factors than those with SCLC. No relation was observed among the expression of drug resistance factors and TNM stage and cell differentiation. The-expression rate was as follows: Pgp + MRP :41.6%, P-gp + LRP :35.0%, MRP + LRP :53.3%, MRP + GST-π:50.0%, LRP + GST-π: 58.3%, Pgp + GST-π:45.0%. P-gp + MRP + LRP + GST-π:20.0%. Among them, significant relation was detected between P-gp and MRP ( rs = 0.756, P < 0. 0 ), between P-gp and LRP ( rs = 0.689, P < 0.01 ), between MRP and LRP (rs = 0.669, P < 0.01 ), between MRP and GST-π( rs = 0.546, P < 0.01 ), between LRP and GST-π ( rs = 0.848, P <0.01 ), between P-gp and LRP( rs =0.535 ,P <0.01 ). Conclusions The Multi-drug resistance in lung cancer patients is affected by various multidrug resistance factors. The drug resistance factors' expression is related to histology, but not to TNM stage end cell differentiation.

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