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Co-expression and clinical significance of multi-drug resistance factors in lung cancer

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WANG Chun(Department of Respiratory, People's Hospital of Liaoning Province, Shen yang 110016, China)
ZHANG Xiao-yu(Department of Respiratory, People's Hospital of Liaoning Province, Shen yang 110016, China)
HUANG Jian-ning(Department of Respiratory, People's Hospital of Liaoning Province, Shen yang 110016, China)
XIAO Ming-ming()
JING Shi-bing()
Journal Title:
Volume 06, Issue 01, 2011
Key Word:
Lung neoplasms;Multi-drug resistance-associated proteins;Immunohistochemistry method

Abstract: Objective To study the expression,co-expression, and clinical significance of four multi-drug resistance factors in lung cancer. Methods The P-glycoprotein (P-gp), mullidrug resistance-associated protein ( MRP, lung resistance protein ( LRP), glutathione-S-transferase (GST-π) of 60 lung cancer patients were detected by immunohistochemical methods. Results The positive drug resistance rate of P-gp, MRP, LRP, GST-π was 53.3% (32/60) ,63.3% (38/60) ,70.0% (42/60) ,80.0% (48/60) respectively. Patients with NSCLC had significantly higher expression of the drug resistance factors than those with SCLC. No relation was observed among the expression of drug resistance factors and TNM stage and cell differentiation. The-expression rate was as follows: Pgp + MRP :41.6%, P-gp + LRP :35.0%, MRP + LRP :53.3%, MRP + GST-π:50.0%, LRP + GST-π: 58.3%, Pgp + GST-π:45.0%. P-gp + MRP + LRP + GST-π:20.0%. Among them, significant relation was detected between P-gp and MRP ( rs = 0.756, P < 0. 0 ), between P-gp and LRP ( rs = 0.689, P < 0.01 ), between MRP and LRP (rs = 0.669, P < 0.01 ), between MRP and GST-π( rs = 0.546, P < 0.01 ), between LRP and GST-π ( rs = 0.848, P <0.01 ), between P-gp and LRP( rs =0.535 ,P <0.01 ). Conclusions The Multi-drug resistance in lung cancer patients is affected by various multidrug resistance factors. The drug resistance factors' expression is related to histology, but not to TNM stage end cell differentiation.

  • [1]Rolff J,Dorn C,Merk J,et al.Response of Patient-Derived NonSmall Cell Lung Cancer Xenografts to Classical and Targeted Therapies Is Not Related to Multidrug Resistance Markers.J Oncol,2009:814140.
  • [2]Shi H,Lu D,Sbu Y,et al.Expression of multidrug resistance-related proteins p-glycoprotein,glutathione-s-transferases,topoisomerase-Ⅱ and lung resistance protein in primary gastric cardiac adenocarcinoma.Hepatogastroenterology,2008,55 (86-87):1530-1536.
  • [3]Oue T,Yoneda A,Uehara S,et al.Increased expression of multidrug resistance-associated genes after chemotherapy in pediatric solid malignancies.J Pediatr Surg,2009,44(2):377-380.
  • [4]Huang WT,Huang CC,Weng SW,et al.Expression of the multidrug resistance protein MRP and the lung-resistance protein LRP in nasal NK/T cell lymphoma:further exploring the role of P53 and WT1 gene.Pathology,2009,41 (2):127-132.
  • [5]Bouhamyia L,Chantot-Bsstaraud S,Zaidi S,et al.Immunolocalization and cell expression of lung resistance-related protein (LRP)in normal and tumoral human respiratory cells.J Histochem Cytochem,2007,55 (8):773-782.
  • [6]Gangemi R,Paleari L,Orengo AM,et al.Cancer stem cells:a new paradigm for understanding tumor growth and progression and drug resistance.Curr Med Chem,2009,16(14):1688-1703.
  • [7]Filomeni G,Turella P,Dupuis ML,et al.6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol,a specific glutathione S-transferase inhibitor,overcomes the multidrug resistance (MDR)-associated protein 1-mediated MDR in small cell lung cancer.Mol Cancer Ther,2008,7 (2):371-379.
  • [8]de Figueiredo-Pontes LL,Pinto MC,et al.Determination of P-glycoprotein,MDR-related protein 1,breast cancer resistance protein,and lung-resistance protein expression in leukemic stem cells of acute myeloid leukemia.Cytometry B Clin Cytom,2008,74 (3):163-168.
  • [9]Kourti M,Vavatsi N,Gombakis N,et al.Expression of multidrug resistance 1 (MDR1),multidrug resistance-related protein 1 (MRP1),lung resistance protein (LRP),and breast cancer resistance protein (BCRP) genes and clinical outcome in childhood acute lymphoblastic leukemia.Int J Hematol,2007,86 (2):166-173.
  • [10]Chakova NN,Mikhalenko EP,Polonetskaia SN,et al.GST polymorphism and cytogenetic changes in lung tissues of lung cancer patients.Tsitol Genet,2009,43(1):48-53.
  • [11]Perez JL,Jayaprakasha GK,Valdivia V,et al.Limonin methoxylationinfluences the induction of glutathione S-transferase and quinone reductase.J Agric Food Chem,2009,57(12):5279-5286.
  • [12]Vlachogeorgos GS,Manali ED,Blana E,et al.Placental isoform glutathione S-transferase and P-glycoprotein expression in advanced nonsmall cell lung cancer:association with response to treatment and survival.Cancer,2008,114(6):519-526.
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