Abstract: Objective To observe the changes and the clinical significance of fibrinolysis in coronary heart disease(CHD) patients with angina pactoris (AP). Methods Levels of plasmin plasminogen activator inhibitor-1(PAI-1), tissue-type plasminogen activator( t-PA), fibrinogen (FIB)in 110 CHD patients with AP and 20 normal cases as control group were analyzed. Results Levels of PAI-1, FIB in CHD patients with AP[(260 ± 8 ) AU/L,(3.6 ± 1.0) g/L] were significantly higher than those in control cases [(260 ± 8 ) AU/L, (3.6 ± 1.0 ) g/L], and those of t-PA were significantly lower than those in control cases. Level of t-PA in patients with coronary heart disease [(240 ± 7) IU/L] was significantly lower than that in the control group[(290 ± 9) IU/L,P < 0. 01]. Levels of PAI-1 ,FIB in unstable angina(UA) patients with UA heart events were significantly higher than those in patients with stable angina (SA). Level of t-PA in patients with UA was significantly lower than that in patients with SA (P <0. 01 ). Levels of PAI-1, FIB in patients with AP events were significantly higher than those in patients without AP events. Levels of t-PA in patients with AP were significantly lower than those in patients without AP events.Conclusions There is abnormal fibrinolysis function in CHD patients with AP, specially in patients with UA or with AP events, which might be play an important rule in coronary heart disease (CHD) patients with angina pactoris.