Investigation of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor concentrations in serum and cerebral spinal fluid in patients of clinically isolated syndrome
- Author:
- No author available
- Journal Title:
- CHINA MEDICINE
- Issue:
- 12
- DOI:
- 10.3760/cma.j.issn.1673-4777.2010.12.006
- Key Word:
- 临床孤立综合征;多发性硬化;脑源性神经营养因子;胶质细胞源性神经营养因子类;Clinically isolated syndrome;Multiple sclerosis;Brain-derived neurotrophic factor;Glial cell line-derived neurotrophic factors
Abstract： Objectives To investigate brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) concentrations in serum and cerebral spinal fluid (CSF) in patients of clinically isolated syndrome (CIS). The first presentation of multiple sclerosis (MS) and the neuroprotective effects were observed.Methods Twenty-seven patients with CIS and twenty-one controls were investigated. The disability severity of CIS patients in attack period was assessed by the Expanded Disability Status Scale (EDSS). The oligoclonal band in ser um and CSF were detected and MRI scanning of brain, spinal cord or optic nerve was examined. BDNF and GDNF concentrations in serum and CSF were assessed by Liquid Assay. Results There were no significant differences of BDNF [ (5. 981 ±0.995 ) μg/L in serum and (0. 178 ±0.008) μg/L in CSF] and GDNF [ (0. 039 ±0.007) μg/L in serum and (0. 082 ±0.011 ) μg/L in CSF] concentrations in serum and CSF from patients with CIS on attack and that from controls ( P ＞ 0. 05 ). There was a positive correlation between BDNF and GDNF concentrations in CSF (r = 0. 777 ,P = 0. 000), but no correlation between BDNF and GDNF concentrations in serum (r = -0. 375, P =0. 126). There were no correlations of BDNF and GDNF concentrations in serum and CSF with EDSS, blood brain barrier index, Delpech index, Tourtellotte synthesis rate and brain atrophy (P ＞ 0. 05 ). Conclusions The level of BDNF in patients with CIS is correlated with that of GDNF, which may have a synergistic neurotrophic effect on CIS.BDNF and GDNF are not associated with the blood-brain barrier destruction and IgG synthesis in central nervous system. However, associations of BDNF and GDNF with functional disability and neuron atrophy in CIS patients still need further studies.
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