Abstract: Objective To analyze the reliability of indication abnormality of the Mindray BC-5500 auto hematology analyzer. Methods Manual stained differentiations were performed on samples of indication abnormality of the Mindray BC-5500 auto hematology analyzer Results The Mindray BC-5500 auto hematology analyzer test showed the predictive value of positive of immature cell,left shift,atypical lymphocyte and PLT clumps were 98.8%,98.8%,96.4%,100%. Conclusion The Mindray BC-5500 auto hematology analyzer has high reliability of indication abnormality.