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Potential role and influencing parameters of serum urea nitrogen among hospitalized older adults

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HUANG Ying-shuo(Department of Geriatrics, First Hospital, Peking University, Beijing 100034, China)
LIU Mei-lin(Department of Geriatrics, First Hospital, Peking University, Beijing 100034, China)
GAO Shi-qin()
LI Xue-ying()
Journal Title:
Volume 05, Issue 10, 2010
Key Word:
Renal insufficiency;Aged;Blood urea nitrogen;Glomerular filtration rate

Abstract: Objectives To explore influencing parameters of serum urea nitrogen and potential role of serum urea nitrogen on estimating renal function among hospitalized older adults. Methods This study was based on a chart review of group of hospitalized older adults who were consecutively admitted to geriatrics ward between January 1996 to December 2009. The patients who were 60 years old or above and had renal function measured by 99Tcm-diethylene triamine pentaacetic acid ( 99 Tcm-DTPA) were eligible. The clinical and biochemical indexes information were collected. Simple unadjusted associations between BUN and other parameters were obtained by univarible analysis. Any variable with P <0.05 was selected for multivariable analysis. The relationship between BUN and renal function based on 99Tcm-DTPA was further examined using receiving operational curve (ROC). Results A total of three hundred and sixty-two cases were eligible for this study. Among them, 193 were males and 169 were females.The average was 71.8 ±6.69 year old. For the normal GFR group, the serum levels of BUN was significantly lower than abnormal group (6.4 ± 2.3 mmol/L vs 8.7 ± 3.7 mmol/L, P = 0.000). Both BUN and Cr were statistically negatively associated with GFR (correlation coefficient was -0. 452 and -0. 589, respectively). The area under ROC curve of BUN and Cr were 0.726 and 0. 792 respectively. In multivariable analysis, age, gender, Cr, UA,ALB/Cr ratio and T2DM were statistically associated with GFR, with OR of 1. 048 (95% CI 1. 006-1. 092), 3. 180(95% CI 1.751-5.775), 1.030(95% CI 1.010-1.052), 1.004(95% CI 1.001-1.007), 0.571 (95% CI0.353-0.923) and 1. 857(95% CI 1. 054-3. 271 ) respectively after adjusting other parameters. Conclusions BUN plays an important role of estimating renal function in hospitalized older adults. Aging, gender, serum Cr and serum ALB/Cr ratio have correlation with serum BUN level. These related parameters should be taken into consideration when estimating renal function.

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