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Expression and analysis of serum interleukin-19 in patients with chronic obstructive pulmonary disease and periodontitis

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Author:
LIN Mei(Department of Stomatology, Beijing Chaoyang Hospital of the Capital University of Medical Sciences, Beijing 100020,China)
LIN Ting(Department of Stomatology, Beijing Chaoyang Hospital of the Capital University of Medical Sciences, Beijing 100020,China)
ZHANG Jing(Department of Stomatology, Beijing Chaoyang Hospital of the Capital University of Medical Sciences, Beijing 100020,China)
LI Yi-zi(Department of Stomatology, Beijing Chaoyang Hospital of the Capital University of Medical Sciences, Beijing 100020,China)
ZHANG Liang-qiong(Department of Stomatology, Beijing Chaoyang Hospital of the Capital University of Medical Sciences, Beijing 100020,China)
PANG Bao-sen()
WANG Zuo-min(Department of Stomatology, Beijing Chaoyang Hospital of the Capital University of Medical Sciences, Beijing 100020,China)
Journal Title:
CHINA MEDICINE
Issue:
Volume 05, Issue 07, 2010
DOI:
10.3760/cma.j.issn.1673-4777.2010.07.002
Key Word:
Periodontitis;Pulmonary disease, chronic obstructive;Serum;Interleukin-19

Abstract: Objective Periodontitis is an inflammatory disease which may be associated with chronic obstructive pulmonary disease (COPD). Interleukin-19 (IL-19) might be involved in the common inflammatory mechanisms. This study investigated the association of serum levels of IL-19 with periodontitis and COPD in a Chinese population. Methods Fifty-one patients with chronic obstructive pulmonary disease, sixty-one patients with periodontitis, ninety-seven patients with both COPD and periodontitis and twenty-two healthy people were included in the study. The blood serum IL-19 levels was detected by ABC-ELISA. Results The differences in IL-19 expression were significant both between periodontitis group and non-periodontitis group, COPD group and non-COPD group (P < 0.05). However, there was no interaction detected between the two diseases on IL-19 expression. Conclusion Serum IL-19 level increases in both periodontitis patients and COPD patientsand IL-19 might be associated with the pathogenesis of periodontitis and COPD.

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