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Measurement and clinical significance of plasma neutropil gelatinase-associated lipocalin concentration in critically ill patients

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Author:
YU Xue-tao(Department of Intensive Care Unit, First Affiliated Hospital of Medical College of Shantou University, Shantou 515041,China)
DU Ze-peng()
XU Li-yan()
NIU Yong-dong()
FANG Wei-qiang(Department of Intensive Care Unit, First Affiliated Hospital of Medical College of Shantou University, Shantou 515041,China)
LI En-min()
Journal Title:
CHINA MEDICINE
Issue:
Volume 05, Issue 07, 2010
DOI:
10.3760/cma.j.issn.1673-4777.2010.07.001
Key Word:
Neutrophil gelatinase-associated lipocalin;Enzyme-linked immunosorbent assay;Critically ill patient;Acute physiology and chronic health evaluation

Abstract: Objective To detect the concentration of plasma neutrophil gelatinase-associated lipocalin (NGAL) and the clinical significance in critically ill patients. Methods Fifty-four critically ill patients in ICU were enrolled in the present study with 23 health persons as controls. Plasma NGAL concentration was measured by enzyme-linked immunosorbent assay (ELISA) on the 1 st and 7th day from 54 adult patients in ICU and the controls (control group). Results The plasma NGAL concentrations of ICU patients were significantly higher than those of the controls (P <0.001 ). NGAL concentrations were no significant difference between the Death group and the Survival group on the 1 st day(P = 0. 259). But there was a markedly significant difference in Acute Physiology and Chronic Health Evaluation (APACHE) Ⅱ scores (P <0. 001 ). The APACHE Ⅱ scores on the 7th day significantly decreased in the improved patients (P =0.019) and showed a subtle tendency of increase in the deteriorated patients ( P =0.403) in comparison to the first day. The plasma NGAL levels followed the same trends, but showing a significant increase even in deteriorated patients ( P = 0. 016 and P= 0. 034, respectively). Conclusions The plasma NGAL concentrations of critically ill patients is significantly increased. Combined with APACHE Ⅱ scores,it can provide useful and available data of the disease state of critically ill patients.

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