Measurement and clinical significance of plasma neutropil gelatinase-associated lipocalin concentration in critically ill patients
- Author:
- No author available
- Journal Title:
- CHINA MEDICINE
- Issue:
- 7
- DOI:
- 10.3760/cma.j.issn.1673-4777.2010.07.001
- Key Word:
- 中性粒细胞明胶蛋白酶;酶联免疫吸附测定;危重患者;急性病生理学和长期健康评估;Neutrophil gelatinase-associated lipocalin;Enzyme-linked immunosorbent assay;Critically ill patient;Acute physiology and chronic health evaluation
Abstract： Objective To detect the concentration of plasma neutrophil gelatinase-associated lipocalin (NGAL) and the clinical significance in critically ill patients. Methods Fifty-four critically ill patients in ICU were enrolled in the present study with 23 health persons as controls. Plasma NGAL concentration was measured by enzyme-linked immunosorbent assay (ELISA) on the 1 st and 7th day from 54 adult patients in ICU and the controls (control group). Results The plasma NGAL concentrations of ICU patients were significantly higher than those of the controls (P ＜0.001 ). NGAL concentrations were no significant difference between the Death group and the Survival group on the 1 st day(P = 0. 259). But there was a markedly significant difference in Acute Physiology and Chronic Health Evaluation (APACHE) Ⅱ scores (P ＜0. 001 ). The APACHE Ⅱ scores on the 7th day significantly decreased in the improved patients (P =0.019) and showed a subtle tendency of increase in the deteriorated patients ( P =0.403) in comparison to the first day. The plasma NGAL levels followed the same trends, but showing a significant increase even in deteriorated patients ( P = 0. 016 and P= 0. 034, respectively). Conclusions The plasma NGAL concentrations of critically ill patients is significantly increased. Combined with APACHE Ⅱ scores,it can provide useful and available data of the disease state of critically ill patients.
- [1]王朝阳,许丽艳,荣举,等.NGAL蛋白Ni2+-金属鏊合层析纯化及其鉴定[J].2004,(2).
- [2]Miller MR,Zhan C.Excess length of stay, charges, and mortality attributable to medical injuries during hospitalization.[J].2003,290(14).
- [3]L, Kjeldsen,A H, Johnsen,H, Sengel?v,etc.Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase.[J].1993,268(14).
- [4]A M, Elneihoum,P, Falke,L, Axelsson,etc.Leukocyte activation detected by increased plasma levels of inflammatory mediators in patients with ischemic cerebrovascular diseases.[J].1996,27(10).
- [5]W A, Knaus,E A, Draper,D P, Wagner,etc.APACHE II: a severity of disease classification system.[J].1985,13(10).
- [6]Dent C,Bean J,Shao M,etc.Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery.[J].2005,365(9466).
- [7]Pasquale Piccinni,Paolo Lentini,Massimo de Cal,etc.Plasma neutrophil gelatinase-associated lipocalin is an early biomarker for acute kidney injury in an adult ICU population[J].2010,36(3).
- [8]Evodia E,Ntetsika K,Haliassos A,etc.Urinary neutrophil gelatinase-associated lipocalin (NGAL) as an early marker of acute kidney injury in critically ill multiple trauma patients.[J].2009,47(1).
- [9]Cvijanovich N,Ma Q,Devarajan P,etc.Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock.[J].2008,36(4).
- [10]M, Bj?rkqvist,J, K?llman,G, Fjaertoft,etc.Human neutrophil lipocalin: normal levels and use as a marker for invasive infection in the newborn.[J].2004,93(4).