Abstract: Objective To study the safety and efficacy of high-power greenlight photoselective vaporization prostatectomy (PVP) and transurethral resection of prostate in treating benign prostatic hyperplasia (BPH).Methods A total of 216 patients with symptomatic bladder outlet obstruction due to BPH underwent PVP and TURP via transurethral.The therapeutic results were assessed using following variables: blood loss, operative time,indwelling catheterization, mean Qmax, IPSS, QOL and the sexual function.Results The PVP and TURP was successfully performed on all the 216 patients with BPH.The mean operative time was (45 ± 22)min (range, 20 ~160 min), no patients required blood transfusion.The mean catheterization time was (34 ±27)h (range,48~96 h) in all.Postoperatively 2 cases had transient dysuria and 2 cases experienced delayed hematuria.128 cases were followed up 3 months after treatment.The mean Qmax increased from (5.9 ± 2.1) ml/s to (18.4 ±2.5) ml/s;mean IPSS and QOL were improved significantly and significant difference was found(P <0.05).The 71 cases with sexal function still remained potent postoperatively.Conclusion The PVP and TURP is safe and effective relief for patients with obstructive BPH with minimal invasion.