Abstract： Objective To explore the effects of atorvastatin on carotid atherosclerosis hypertension patients with normal blood lipid and high sensitivity C-reactive protein.Methods One hundred and sixty-three hypertension patients with normal blood lipid and high sensitivity C-reactive protein were randomly divided into the atorvastatin group (10 nag atorvastatin per day, n =91)and control group(n =92).The therapeutic course was 1 year. Results One year follow-up showed that total cholesterol(TC) (3.01±0.48 vs 4.73 ±0.52), low density lipoprotein cholesterin (LDL-C) (1.94 ±0.37 vs 2.71 ±0.42), while hs-CRP (2.3 ± 0.6 vs 15.1 ± 3.4), leukin-6 (91.41± 25.53 vs 163.41 ± 23.96), tumor necrosis factor-α (2.17 ± 0.46 vs 3.28 ± 0.51) and integral of carotid atherosclerosis were all significantly decreased (P ＜ 0.05) after atrovastatin treatment, and the side effect is mild.Conclusion Atorvastatin can effectively prevent carotid atherosclerosis in hypertension patients with normal blood lipid and high sensitivity C-reactive protein.