Abstract: Objective Tramesophageal echocardiography(TEE) and transcranial Doppler (TCD) examination with contrast injection can both be used to search for a patent foramen ovale(PFO).We compared the accuracy of these techniques for identifying a PFO in patients with migraine.Methods PFO was assessed by performing TEE and TCD with Ⅳ injection of agitated saline in 41 subjects with migraine with aura (n=26) and without aura (n=15) in Oct-patient department(OPD).Results We found 22 PFOs with both TCD and TEE.Both contrast tests were negative in 16 patients.For 1 patient,the contrast test was positive only with TEE.And 2 were positive only in TCD.In comparison with TEE,adopted as the "gold standard",TCD had a sensitivity of 94% (16 0f 17),specificity of 92% (17 of 18).Conclusions cTCD is an examination with wish sensitivity and high specificity in detectins a PFO.