Abstract: Objective To evaluate the glycosylated hemoglobin (HbA1c) level in patients with acute myocardial infarction.Methods The data of 474 in-hospital patients with ST-elevation myocardial infarction were collected from database of Beijing Anzhen Hospital from January to December 2008.The patients were divided into two groups according to the level of HbA1c:HbAlc≥6.5% group and control group (HbAlc<6.5%).The prognosis of two groups were observed.Results Age,smoke,ischemic time,cases of coronary angiography,successful reperfusion rate,in-hospital drug us were no significant different between two groups(P>0.05).Compared with the control group,history of hypertension(P=0.008) and diabetes (P=0.000),blood glucose (P=0.000),triplevessel disease (P=0.031),male (P=0.006),LVEF (P=0.023) and single-vessel disease (P=0.040) were significantly different in HbA1c≥6.5% group.In HbA1c≥6.5% group,there was higher incidence of heart failure (P=0.041),in-hospital mortality (P=0.033),cardiogenic shock (P=0.038).Logistic analysis showed that HbA1c≥6.5% were independent factors of in-hospital mortality(OR=0.932,95% CI:0.311-1.124,P=0.044) and the rate of heart failure (OR=1.467,95% CI:0.473-3.149,P=0.047).Conclusions The high level of HbA1c is a powerful predictor of in-hospital mortality and incidence of heart failure in patients with acute myocardial infarction.The prognosis of AMI can be improved by the control of blood sugar.