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The impact of spironolactone on Tel index in patients with acute myocardial infarction

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Author:
CHEN Hong-ying("Department of Cardiology, People's Hospital of Yuhuangding, Yantai 264000, China)
LIN Jian-jun()
Journal Title:
CHINA MEDICINE
Issue:
Volume 5, Issue 03, 2010
DOI:
10.3760/cma.j.issn.1673-4777.2010.03.005
Key Word:
Acute myocardial infarction; Spironolactone; Tei index

Abstract: Objectives To study the impact of spironolactone on Tei index in patients with acute myocardial infarction(AMI). Methods Ninety cases of patients with ST-segment elevation myocardial infarction were selected and randomly divided into two groups. Forty-five cases in control group were given routine therapy and 45 cases in spironoiactone group were given 20 mg spironolactone once a day on the basis of the same routine therapy as con-trois. The levels of Tei index were measured before and after the treatment of 6 months. Results There was no sig-nificant difference between two groups before treatment (P >0.05). After treatment Tel index of spironolactone group(0.53±0.16) was significantly lower than control group (0.62±0.14) (P<0.05). Conclusions Spironolactone can reduce the level of Tei index and improve the cardiac function of patients with AMI.

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