Your Position: Home > Journal List > CHINA MEDICINE > Paper

The impact of spironolactone on Tel index in patients with acute myocardial infarction

( views:, downloads: )
CHEN Hong-ying("Department of Cardiology, People's Hospital of Yuhuangding, Yantai 264000, China)
LIN Jian-jun()
Journal Title:
Volume 5, Issue 03, 2010
Key Word:
Acute myocardial infarction; Spironolactone; Tei index

Abstract: Objectives To study the impact of spironolactone on Tei index in patients with acute myocardial infarction(AMI). Methods Ninety cases of patients with ST-segment elevation myocardial infarction were selected and randomly divided into two groups. Forty-five cases in control group were given routine therapy and 45 cases in spironoiactone group were given 20 mg spironolactone once a day on the basis of the same routine therapy as con-trois. The levels of Tei index were measured before and after the treatment of 6 months. Results There was no sig-nificant difference between two groups before treatment (P >0.05). After treatment Tel index of spironolactone group(0.53±0.16) was significantly lower than control group (0.62±0.14) (P<0.05). Conclusions Spironolactone can reduce the level of Tei index and improve the cardiac function of patients with AMI.

  • [1]Brilla CG,Zhou G,Matsubara L,et al.Collagen metablism in cultured adult rat cardiac fibreblasts:response to angiotensin Ⅱ and aldosterone.J Mol Cell Cardial,1990,26 (7):809-820.
  • [2]中华医学会心血管病学分会,中华心血管病杂志编辑委员会,中国循环杂志编辑委员会.急性心肌梗死诊断和治疗指南.中华心血管病杂志,2001,29(12):710-725.
  • [3]马爱群,胡大一.心血管病学.北京:人民卫生出版社,2005:94.
  • [4]Patten RD,Aronovitz MJ,Einstein M,et al.Effects of angioten-sion Ⅱ receptor blockade verses angiotension-converting-enzyme in-hibition on ventricular remodelling following myocardial infarction in the mouse.Clin Sci(Lond),2003,104(2):109-118.
  • [5]顾复生.醛同酮对心力衰竭的有害作用与醛固酮(受体)拮抗剂.中国循环杂志,2002,17(4):264-265.
  • [6]程蕾蕾,舒先红,韩蓓蓓,等.Tei指数评价冠心病患者心功能的临床研究.中国超声医学杂志,2003,19(9):664-667.
  • [7]Kim WH,Otsuji Y,Seward JB,et al.Estimation of left ventricular function in right ventricular volume and pressure overload.Detec-tion of early left ventricular dysfunction by Tei index.Jpn Heart J,1999,40(2):145-154.
  • [8]Parthenakis FI,Kanakaraki MK,Kanoupakis EM,et al.Value of doppler index combining systolic and diastolic myocardial perform-ance in predicting cardiopulmonary exercise capacity in patients with congestive heart failure:effects of dobutamine.Chest,2002,121(6):1935-1941.
  • [9]张逢博.心功能综合指数评价无创正压通气对急性左心衰竭患儿心功能影响的研究.中国医药,2009,4(10):812-814.
  • [10]蔡久英,王建飞,高薇,等.苯那普利与螺内酯合用治疗高血压性心脏病心力衰竭临床疗效观察.中国医药,2008,3(3):174-175.
  • [11]Pitt B,Remme W,Zannad F,et al.Eplerenone,a selective aldo-sterone blocker,in patients with left ventricular dysfunction after myocardial infarction.N Engl J Med,2003,348 (14):1309-1321.
  • [12]邱洪,杨跃进,田毅,等.安体舒通对大鼠心肌梗死后心室重构和心肌间质胶原的影响.中国循环杂志,2003,18(6):458-461.
  • [13]Schmidt BM,Schmieder RE.Aldosterone-induced cardiac dam-age:focus on blood pressure independent effects.Am J Hypertens,2003,16(1):80-86.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615