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Obesity and cigarette smoking impaired arterial stiffness with oxidative stress

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OUYANG Chi(Department of Basic Medicine,Xiang-nan University, Chenzhou 423000, China)
CHEN Xiao-lan(Department of Basic Medicine,Xiang-nan University, Chenzhou 423000, China)
MO Yan-xiu(Department of Basic Medicine,Xiang-nan University, Chenzhou 423000, China)
TANG Yin-juan(Department of Basic Medicine,Xiang-nan University, Chenzhou 423000, China)
LI Shi-wang(Department of Basic Medicine,Xiang-nan University, Chenzhou 423000, China)
LIU Ke-feng(Department of Basic Medicine,Xiang-nan University, Chenzhou 423000, China)
Journal Title:
Volume 5, Issue 03, 2010
Key Word:
Obesity; Cigarette smoking; Arterial stiffness; Oxidative stress

Abstract: Objective To investigate the effect of obesity and cigarette smoking on arterial stiffness with ox-idative stress. Methods Eighty five healthy male students were divided into two groups according to BMI or waist circumference. Group A was control group(n=41), group B was obese group(n =44) which was given cigarette smoking for 25 days. Then, arterial stiffness, plasma malonaldehyde(MDA) and uric acid(UA) levels of each sub-ject in group A, pre-and post-cigarette smoking of group B were analyzed. Results The arterial stiffness (1.78±0.26 vs 1.97±0.38, P <0.05), plasma MDA(3.88±1.13 vs 4.32±1.56, P<0.05) and UA(295±43 vs 361 ± 57, P < 0.05) levels were significance higher in pre-cigarette smoking of group B compared with group A. The arterial compliance was significance lower(1.97±0.38 vs 1.54±0.32, P <0.01) and the plasma UA level(295±43 vs 472±39, P <0.01) was significance higher in post-cigarette smoking of group B than that in other groups.Conclusions The plasma MDA and UA levels increased, which were product of oxidative stress. These indicated that the disorder of oxidation-antioxidation impaired arterial stiffness and arterial compliance, also exacerbated the morbidity and mortality of cardiovascular disease in obesity and cigarette smoking.

  • [1]武阳丰,马冠生,胡永华,等.中国居民的超重和肥胖流行现状.中华预防医学杂志,2005,39(9):316-320.
  • [2]Wang TJ,Parise H,Levy D,et al.Obesity and the risk of new-on-set atrial fibrillation.JAMA,2004,292(20):2471-2477.
  • [3]Chemla D,Antony I,Leearpentier Y,et al.Contribution of sys-temic vascular resistance and total arterial compliance to effective arterial elastance in humans.Am J Physiol Heart Circ Physiol,2003,285 (2):H614-H620.
  • [4]Cohn JN,Duprez DA,Crandits CA.Arterial elasticity as part of a comprehensive assessment of cardiovascular risk and drug treat-ment.Hypertension,2005,46(1):217-220.
  • [5]Wildman EP,Farhat GN,Patel AS,et al.Weight change is asso-ciated with change in arterial stiffness among healthy young adults.Hypertension,2005,45 (2):187-192.
  • [6]Yasmin,McEniery CM,Wallace S,et al.C-reactive protein is as-sociated with arterial stiffness in apparently healthy individuals.Ar-terioscler Thromb Vasc Biol,2004,24(5):969-974.
  • [7]Nakagawa T,Tuttle KR,Short RA,et al.Hypothesis:fructose-in-duced hyperuricemia as a caual mechanism for the epidemic of the metabolic syndrome.Nat Clin Nephrol,2005,1 (2):80-86.
  • [8]Helmersson J,Larsson A,Veseby B,et al.Active smoking and a history of smoking are associated with enhanced prostaglandin F (2alpha),interleukin-6 and F2-isoprostane formation in elderly men.Atheroaclerosis,2005,181 (1):201-207.
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