Abstract： Objective To observe the sensitization changes of SKOV3. ip1 cells exposed to taxel when the expression of Her-2 in SKOV3. ip1 ceils was depressed. Meshods 1. Cell culture: SKOV3. ip1 cells and lower Her-2 expressed SKOV3. ip1 expressed SKOV3. ip1 cells was detected by Western blot. 3. MTT Test : SKOV3. ip1 cells were exposed to different dose taxel (6,12, 24,48,96 μg/ml), The MTT method was used to detect the inhibi-tion rate of SKOV3. ip1 cells exposed to taxel and the inhibition rate of SKOV3. ip1 cells that express different Her-2 level was compared. Results When exposed to(6,12, 24,48 μg/ml)taxel dose, the inhibition rate of lower Her-2 expressed SKOV3. ip1 cells were (45.50±0.95)%, (65.37±0.56)%, (76.83±0.27)% and (81.83±0.69)%. While the inhibition rate of SKOV3. ip1 cells were(36.13±1.74)%, (56.43±2.19)%, (67.57±1.96) % and(74.30±1.10) %. The difference were obviously (P < 0.01). Conclusion The sensitization of SKOV3. ip1 cells to taxel was increased when the expression of Her-2 in the cells was depressed.