Your Position: Home > Journal List > CHINA MEDICINE > Paper

The correlation between vascular-associated factors and severity of coronary artery stenosis in patients with hypertension

( views:, downloads: )
REN Jun-mei(Department of Cardiology,Hospital of Shanxi Jincheng Anthracite Coal Company,Jincheng 048006,China)
WANG Rui-ying()
LIU Yi-jian(Department of Cardiology,Hospital of Shanxi Jincheng Anthracite Coal Company,Jincheng 048006,China)
LI Shu-feng(Department of Cardiology,Hospital of Shanxi Jincheng Anthracite Coal Company,Jincheng 048006,China)
TIAN Shu-wen(Department of Cardiology,Hospital of Shanxi Jincheng Anthracite Coal Company,Jincheng 048006,China)
Journal Title:
Volume 5, Issue 01, 2010
Key Word:
Hypertension;Coronary artery remodeling;Adiponeetin;Matrix metalloproteinases-9:Angiotension Ⅱ: Endothelin

Abstract: Objective To investigate the correlation among plasma APN,MMP-9,Ang Ⅱ,ET-1 levels and severity of coronary artery stenosis.Methods The plasma APN,MMP-9,AngⅡ,ET-1 levels were measured.The degree of artery stenosis was confirmed by coronalyangiographies and assessed quantitatively with Gensini score.Results In old patients with hypertension,the plasma APN level was significantly lower than that of control group (P<0.01).The plasma MMP-9,AngⅡ,ET-1 levels were significantly higher than that of control group(P<0.01).Gensini score increased as the APN level decreased(P<0.05)and the MMP-9,AngⅡ,ET-1 levels increased(P<0.05).The plasma levels of MMP-9,AngⅡ,ET-1 was found to be positively correlated with Gensini 8core(r=0.841,P<0.01;r=0.760,P<0.01;r=0.880,P<0.01).The plasma levels of adiponectin was found to be negatively correlated with Gensini score(,=-0.714,P<0.01).Multiple regression analysis showed that MMP-9,AngⅡ,ET-1 levels were independent factors of Gemini score.Conclusions The plasma MMP-9,AngⅡ,ET-1 levels and the plasma adiponeetin level are closely related to the degree of coronary artery and remode1ing in hypertension patients.The research showes that the plasma APN,MMP-9,Ang Ⅱ,ET-1 levels might be involved in the pathophysiologie process of coronary remodeling.

  • [1]Gensini GG.A mole meaningful scoring system for determining the severity of coronary heart diesase.Am J Cardiol,1983,51(3):606.
  • [2]Hopkins TA,Ouchi N,Shibata R,et al.Adiponectin actions in the cardiovascular system.Cardiovaac Res,2007,74(1):11-18.
  • [3]杨婷,王瑞英.高血压病患者血清脂联素水平及与颈动脉硬化的关系.中国医药,2008,3(7):398-399.
  • [4]Ouchi N,Kihara S,Arite Y,et al.Adipocyte-derived plasma protein,adiponectin,suppresses lipid accumulation and class A scavenget receptor expression in human monocyte-derived macrophages.Circulation,2001,103(8):1057-1063.
  • [5]连环,刘福成.冠心病及等危症患者血浆脂联素氮端脑利钠肽前体的相关性研究.中国基层医药,2009,16(4):665-666.
  • [6]Hashimoto N,Kanda J,Nakamura T,et al.Association of hypoadiponectinemia in men with early onset of coronary heart disease and multiple coronary artery stenoses.Metabolism,2006,55(12):1653-1657.
  • [7]Flamant M,Placier S,Dubroca C,et al.Role of matrix metalloproteinases in early hypertensive vascular remodeling.Hypertension,2007,50(1):212-218.
  • [8]崔洪伟,王敏,董秀红,等.血清脂联素水平与原发性高血压患者肾脏损害的关系.中国医药,2009,4(12):961-964.
  • [9]Zhang J,Nie L,Bazavian M,et al.Molecular imaging of activated matrix metallopmteinases in vascular remodeling.Circulation,2008,118(19):1953-1960.
  • [10]Ahmed SH,Clark LL,Pennington WB,et al.Matrix metalloproteinases/tissue inhibitors of metalloproteinases:relationship between changes in proteolytic determinants of matrix composition and structural,functional,and clinical manifestations of hypertensive heart disease.Circulation,2006,113(17):2089-2096.
  • [11]Heeneman S,Sluimer JC,Daemen MJ.Angiotensin-converting enzyme and vascular remodeling.Circ Res,2007,101(5):441-454.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615