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Effects of atorvastatin on left ventricular function in old patients with serious-ischemic coronary artery disease

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Author:
ZHOU Qing(Department of Cardiology,Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Meclicine,Shanghai 200092,China)
CHEN Tian-shi(Department of Cardiology,Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Meclicine,Shanghai 200092,China)
LIU Xiao-hong(Department of Cardiology,Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Meclicine,Shanghai 200092,China)
ZANG Xiao-li(Department of Cardiology,Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Meclicine,Shanghai 200092,China)
WANG Fei(Department of Cardiology,Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Meclicine,Shanghai 200092,China)
LI Yue-hua(Department of Cardiology,Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Meclicine,Shanghai 200092,China)
CHEN Shu-yan(Department of Cardiology,Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Meclicine,Shanghai 200092,China)
Journal Title:
CHINA MEDICINE
Issue:
Volume 5, Issue 01, 2010
DOI:
10.3760/cma.j.issn.1673-4777.2010.01.001
Key Word:
Coronary artery diseases; Atorvastatin;Heart funtion

Abstract: Objective To investigate the effect of different doses of atorvastatin on left ventricular function in old patients with senous ischemic and non-revascularization coronary artery diseases. Methods Fourty patients with serious isehemic coronary artery diseases and improper or unwilling to have revascularization were enrollod.The8e patients randomly received atorvastatin(10 mg/d)or atorvastatin(40 mg/d)and were prospectively followed up for 1 year.Before therapy,we measured plasma concentrations of Pro-brain natriuretic peptides(Pro-BNP),left ventricular end-diastolic dimension(LVEDD),left ventricular end-systolic dimension(LVESD)and left ventricular ejection fraction(LVEF)by echoeardiography.Furthermore these measurements were repeated every 6 months.The serum level of blood lipid,plasma of high-sensitive C-reaction Protein,liver function and creatine kinase were observed and were also tested every 3 months.Results After a follow-up period of 6 months,the level of Pro-BNP decreased and LVEF increased significanfly in both groups(P<0.05).The levels of Pro-BNP and LVESD decreased and LVEF increased significantly in both groups(P<0.01)at the end of 1 year follow-up.The changes of Pro-BNP,LVEDD,LVESD,LVEF showed no significant differences between the two groups.After a follow-up period of 3 months,the level of hs-CRP decreased(P<0.05)in both groups.The level of hs-CRP,TC,LDL-C significantly decreased in both group.No liver danger was observod and the level of creatine kinase did not increase.Conclusions Atorvastatin is effective of treating serious isehemie coronary artery diseases patients and can improve left ventricular function and reduce the level of hs-CRP,BNP.Thereis no serious side effect observed in this study.

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