Abstract： Objective To observe the co-expression of endoglin, vascular endothelial growth factor (VEGF), kinase insert domain containing receptor (KDR), and matrix metalloproteinase-9 (MMP-9) and their role of regulating regional tumor angiogenesis in invasive carcinoma of cervix. Method The expression of endoglin, VEGF, KDR and MMP-9 and the microvessel density (MVD) labeled by CD34 in 15 cases of normal cervical epi-thelium (NCE), 18 cases of cervical intraepithelial neoplasm (CIN) and 75 cases of invasive carcinoma of cervix (ICC) were detected by SP immunohistochemistry technique. Results The positive rote of endoglin, VEGF, KDR and MMP-9 was 6.7%, 26.7%, 13.3% and 20.0% in NCE group; 38.9%, 61.1%, 61.1% and 55.6% in CIN group; 64.0%, 77.3% , 69.3% and 81.3% in ICC group. The positive rate of endoglin, VEGF, KDR and MMP-9 all increased remarkably in 3 groups (P < 0.05). In ICC group, the MVD was positively related to the ex-pression of endoglin(r = 0.499, P < 0.01), VEGF (r = 0.602, P < 0.01), KDR (r = 0.331, P < 0.01) and MMP-9 (r = 0.287, P < 0.05), respectively. In the cases with all positive expression of endoglin, VEGF, KDR and MMP-9 in ICC group, the MVD was significantly higher than those without positive expression (P < 0.01). Conclusion Co-expression of endoglin, VEGF, KDR and MMP-9 may play a key role in up-regulating regional tumor angiogenesis in cervical carcinoma. Co-overexpression of all endoglin, VEGF, KDR and MMP-9 in cervical carcinoma may result in rapid tumor tmgiogenesis.