Abstract： Objective To explore the effect of heparin sodium cream on partial thickness burns. Methods From January 2004 to January 2007, fifty-five cases of deep partial thickness in total burned surface area (TBSA) with 1% to 5% burn wound were treated by Heparin sodium cream(the heparin group). Fifty cases of deep partial thickness burned patients with the same TBSA treated by povidone iodine (the povidone iodine group). Results The average healing time of the heparin group was (18.5±2.2) days and the average healing time of the povidone iodine group was (22.5±3.6) days. Follow-ups during 3 months to 1 year after treatment showed that sear proliferation in the heparin group was much less than that in the povidone iodine group, and even no sear proliferation was observed in some patients. Conclusion Heparin sodium cream on deep partial thickness burns with small burned area could shorten the healing time and inhibit sear proliferation.