Abstract： Objective To observe the distribution of serum croatinine and analyze its associated influence factors in patients underwent coronary angiography. Methods Four hundred and eighty-two consecutive patients recieving coronary angiography from Aug, 2007 to Aug, 2008 at Beijing Anzhen hospital were enrolled. Results 1. The average level of serum creatinine of males (96. 36μmol/L) in male patients was significantly higher than females (83.98 μmol/L) (P < 0.01). The level of serum creatinine increased with severity of CAD (P < 0.01). The prevalence of renal dysfunction was 11.6% in this group. 2. Compared with normal people, the levels of serum creatinine were higher in groups of dyslipidemia, overweight, hypertension, hyperuricaemia, diabetes and smoking (P < 0. 05). The prevalence of renal dysfunction was higher in groups of hypercholesterolaemia, hypertension, diabetes and hyperuricaemia. 3. Hypercholesterolaemia, hypertension, diabetes and hyperuricaemia were main influencing factors of renal dysfunction, with OR 1.36, 1.98, 3.58 and 1.46 (P<0.01). 4. Level of serum creatinine increased significantly with the severity of CAD. Conclusion Gender, lipids, blood pressure, uric acid, body mess index, smoking and diabetes show influence on serum creatinine level. Hyperoholesterolaemia, hyperten-sion and hyperuricaemia are main influencing factors of renal dysfunction.