Abstract： Objective To explore the effect of soluble intercellular adhesion molecule-1 (slCAM-1), soluble vascular cell adhesion molecule 1 (sVCAM-1), soluble E-selecfin ( sE-selectin ), interleukin 4 (IL-4) and interleukin 10(IL-10) on pathogenesis of patient with Allergic rhinitis (AR) and Bronchial asthma. Methods Thirty-three patients with asthma,35 patients with AR, 35 patients with AB accompanying bronchial asthma (BA) and 35 controls were included. The concentration odd sICAM-1 ,sVCAM-1 ,sE-selectin ,IL-4,IL-10 in the sera was measured by double antibody sandwich enzyme-linked immunosorbent assay. Results The level of sICAM-1, sVCAM-1, sE-selectin ,IL-4 , IL-10 greatly increased intreatment group than control group (P <0.01). There was statistical difference of sICAM-I, sVCAM-1, sE-selectin, IL-4, IL-10 between the group of AR accompanying bronchialasthma and the group of bronchial asthma. Conclusion The study shows that both AR and asthma are characterized by means of a similar inflammatory process through upregulation of adhesion molecules. The leveh of soluble adhesion molecules, IL-4, IL-10 are significantly high in AR accompanying bronchial asthma compared with AR and asthma.