Abstract： Objective To explore the intima-media thickness and the spot piece detected by high frequency ultrasonic in patients with carotid disease. Methods Forty eight symptomatic pectoris patients without myocardial infarction disease history, 30 patients with myocardial infarction disease history and 45 normal people were enrolled. The inside-middle membrane thickness (IMT) and manifestation of spot rate of carotid artery were detected by high frequency ultrasonic. Results The myocardial of IMT lacks the blood set (0.88 ± 0. 24) mm and the myocardial infarction set (1.08 ± 0.19)mm, both have no obvious difference, but compare with normal set to have the obvious difference. A manifestation rate of spot: The myocardial lacks the blood set as 58.33% (28/48) ; the myocardial infarction set is 69.99% (21/30) ; the normal set is 13.33% (6/45). Conclusion High frequency ultrasonic detecting carotid artery IMT and an occurrence of spot rates is valuable for patients with coronary artery disease.