Abstract: Objective To study the clinical significance of FIB rinolysis and nitric oxide(NO) in coronary heart disease patients wiht angina pactoris. Methods Levels of plasmin plasminogen activator inhibitor-1 (PAI-1), tissue-type plasminogen activator(t-PA) ,plasminogen, Fibrinogen(FIB) and NO in 63 patients with unstable angina pactoris(UA) ,29 patients with stable angina paetoris(SA) were measured, and 20 normal cases as control group were analyzed in the same ways. Results Levels of PAI-1, FIB in UA patients were significantly higher than in SA patients and in normal cases, those in patients with heart events were also significantly higher than those without heart events; Levels of t-PA,NO in UA patients were significantly lower than in SA patients and in normal cases, those in patients with heart events were also significantly lower than those without heart events; There were no significant differances among of all groups in levels of Pig. Conclusion The abnormality of Fibrinolysis function and decrease of NO levels might be associated with heart events, and the abnormal ityin UA patients was more evident than that in SA patients.