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Protection of p38MAPK inhibitor against myocardial injury in septic rats

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Author:
No author available
Journal Title:
CHINA MEDICINE
Issue:
5
DOI:
10.3760/cma.j.issn.1673-4777.2009.05.002
Key Word:
脓毒症;白细胞介素-1β;肿瘤坏死因子-α;心肌损伤;Sepsis;Interleukin-1β;Tumor necrosis factor-alpha;Myocardial injury

Abstract: Objective To investigate the protection function of p38MAPK inhibitor against myocardial inju-ry in sepsis. Methods The cecal ligation and puncture was adopted to build up sepsis model. The levels of serum CK-MB,TNF-alpha and IL-lbeta at different time points were observed. Results The levels of CK-MB,TNF-alpha and IL-1 beta increased significantly after the CLP operation. The levels of TNF-alpha and IL-1 beta was significantly relat-ed to CK-MB. After administering p38MAPK inhibitor and SB203580, the levels of TNF-alpha and IL-1 beta decreased significantly and the myocardial injury was alleviated. Condusion Excessive secretion of TNF-alpha and IL-1 beta are the main cause of myocardial injury in sepsis. The regulation of the p38MAPK pathway may protect myocardial injury.

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