Abstract： Objective To observe the feasibility and safety of transradial percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction(STEM I). Methods Two hundreds and twenty-five patients with identified STEMI were admitted for emergency PCI from January 2005 to December 2007. Patients were randomized into transradial group (n = 123) and transfemoral group (n = 102). Successful PCI ratio and post-operational complication were recorded and analyzed. Results There was no significant difference between the two groups in age, gender, body mass index, coronary risk factors, territory of MI, culprit vessels, and vascular stenosis degree. Meanwhile the successful PCI ratio did not differ between transradial and transfemoral groups (94.3% vs 92.3%, P > 0.05). There was a significant decrease of post-operational complication in transradiat group compared with transfemoral group (6.5% vs 15.7%, P < 0.05) although the length of hospital stay and the in-hospital main cardiovascular events did not differ. Conclusion Transradial PCI for STEMI is feasible and safe with the similar achievement ratio and decreased post-procedural complication.