Clinical study of nuclear matrix protein in urine for detection of bladder cancer
- Author:
- No author available
- Journal Title:
- CHINA MEDICINE
- Issue:
- 12
- DOI:
- 10.3760/cma.j.issn.1673-4777.2008.12.002
- Key Word:
- 膀胱癌;核基质蛋白;Bladder neoplasms cancer;Nuclear matrix protein
Abstract： Objective To evaluate the clinical efficacy of nuclear matrix protein(NMP)as a marker for detection of bladder cancer.Methods For 96 patients suspected with bladder cancer NMP and cytology were determined in the same voided urine samples.The sensitivity and specificity of NMP and urine cytology were analyzed.Results Fifty-five patients were pathologically diagnosed as transitional cell carcinoma.and 41 cases were other urological conditions.The sensitivity and specificity of NMP were 80.0%and 87.8%respectively.those of urene cytology were 41.8%and 97.6%respectively.The sensitivity of NMP Was significantly better than urinary cytology in detection of bladder cancer(P＜0.05).Conclusion The NMP test iS superior to voided urine cytology in detection of bladder cancer.and it is a effective method for detection of bladder cancer.
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