Effects of Magnolol on death associated protein kinase expression and neuron apoptosis following traumatic brain injury in mice
- Author:
- No author available
- Journal Title:
- CHINA MEDICINE
- Issue:
- 12
- DOI:
- 10.3760/cma.j.issn.1673-4777.2008.12.001
- Key Word:
- 创伤性脑损伤;厚朴酚;死亡相关蛋白激酶;Traumatic brain injury;Magnolol;Death associated protein kinase
Abstract： Objective To observe the effects of magnolol on death assailed protein kinase(DAPK)expression and neuron apoptosis after traumatic brain injury(TBI)in mice.Methods Models of TBI rats were established by free drop impact mode.These 60 adult rats weighed 250～300g were randomly divided into TBI PCR method to determine the expression of DAPK mRNA.TUNEL method was applied to determine neuron apoptosis.Results The expression of DAPKmRNA and apoptosis myocytes significantly increased in brain injury groups decerased significantly than other groups(P＜0.05).Conclusion DAPK is activated in neuron of rats after TBI.The suppression of the expression of DAPKmRNA in models of TBI rats is probably related to protective effect of magnolol on TBI.
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