Abstract： Objective To evaluate the therapeutic efficacy of flupentixol combined with pantoprazole in patients with non-erosive gastroesophgeal reflux disease companied by depression and/or anxiety.Methods Fifty-four patients were randomly divided into three groups(pantoprazole group,flupentixol group and combination group).Each patient was treated for six weeks continnously.The therapeutic efficacy was evaluated by the symptom scores.Results There were certain effects of pantoprazole or flupentixol alone treatment on the improvement of symptoms of NERD.Pantoprazol is a better for relieving acid reflux than flupentixol(P＜0.01),but no difference for relieving heartburn and substernal pain after treatment(P＞0.05);Combined treatment is a better for relieving the symptoms of NERD than pantoprazole or flupentixol treatment alone(P＜0.01).Conclusion Small-dose flupentixol combined with panto prazole show better effect on patients with NERD companied by depression and/or anxiety.