Abstract： Objective To evaluate the correlation between HbA1C and pulse ware velocity(PWV).Methods 127 patients with diabetes mellitus was enrolled into two groups based on HbA1C level:1.Group with increased HbA1C(HbA1C＞6.5%)and the control group(HbA1C≤6.5%).We measured the PWV and blood pressure,nitroglycerin,total cholesterol and blood plasma lipids of all the patients.Results PWV of the patients with HbA1C＞6.5%were significantly higher than of that in control group(P＜0.01).The HbA1C level and systolic pressure was correlated to PWV(P＜0.01).Conclusion There Was strong correlation between HbA1C and PWV.The arteriosclerosis will become more severe if the blood glucose iS not controlled well.Controlling the blood glucose and blood pressure to a proper level is exceedingly important in prevention of complications of large blood vessels in patients with diabetes mellitus.