Your Position: Home > Journal List > CHINA MEDICINE > Paper

Correlation between human metapneumovirus infection and wheezing disease in children

( views:360, downloads:0 )
Author:
LIAO Hua(Department of Pediatric, The Eighth Hospital of Shenzhen Shenzhen 518101, China)
ZHANG Shou-Bin()
ZOU Hong-mei()
WANG Xiao-juan()
GONG Hong-yu()
ZHONG Fu-xia()
HUANG Yan(Department of Pediatric, The Eighth Hospital of Shenzhen Shenzhen 518101, China)
LIN Ji-tao(Department of Pediatric, The Eighth Hospital of Shenzhen Shenzhen 518101, China)
Journal Title:
CHINA MEDICINE
Issue:
Volume 3, Issue 06, 2008
DOI:
Key Word:
Wheezing; Human metapnumo virus; Respiratory syncytial virus

Abstract: Objective To investigate correlation between human metapneumovirus infection and wheezing Disease in children. Methods Seven common respiratory viruses extracted from nasopharyngeal secretion in 124children with Wheezing diseases were analyzed with immunofluorescent assay. Meanwhile, the hMPV gene was detected with RT-nPCR. Results Seventy positive cases were detected in all patients. Among them, 53(42.7% )were common respiratory viruses (39 Respiratory syncytial viruses RSV, 6 influenza virus, 5 adenovirus and 3 par influenza virus). Meanwhile, hMPV gene were detected in 17 cases (13.7%). 2 patients were infected with both RSV and hMPV. The age, gender and clinical manifestations of the children infected with RSV and with hMPV didnt show significant difference ( P > 0.05 ). Conclusion RSV was still the most commonly virus in children Wheezing Disease. Meanwhile, hMPV was another important pathogen. The clinical characteristics of the two viruses were similar.

  • [1]Van den Hoogen BG,De Jong JC,Groen J,et al.A newly discovered human pneumovirus isolated from young children with respiratory tract disease[J].Nat Med,2001,7 (6):719-724.
  • [2]Jose O,Jose AB,Marta AA,et al.Role of Metapneumovirus in Viral Respiratory Infections in Young Children[J].J Clin Micro,2006,44 (8):2739-2742.
  • [3]Sigurs N,Bjamason R,Siguroergsson F,et al.Respiratory syncytial virus broachiolitis in infancy is an importantrisk factor for asthma and allergy at age 7[J].Am J Respir Crit Care Med,2000,161 (5):1501-1507.
  • [4]Poutanen SM,Low DE,Henry B,et al.Identification of severe acute respiratory syndrome in Canada[J].N Engl J Med,2003,348 (20):1995-2005.
  • [5]Williams JV,Harris PA,Tollefson SJ,et al.Human metapneumovirus and lower respiratory tract disease in otherwis healthy infants and children[J].N Eng J Med,2004,350 (5):443-450.
  • [6]朱汝南,钱渊,邓洁,等.北京地区六岁以下儿童急性呼吸道偏肺炎病毒感染[J].中华儿科杂志,2003,41(6):441-444.
  • [7]Jartti T,Van den Hoogen B,Garofalo RP,et al.Metapneumovirus and acute wheezing in children[J].Lancet,2002,360 (9343):1393-1394.
  • [8]Brigitte K,Wolfgang K,Ralf A,et al.Prospective study of human metapneumovirus infection in children less than 3 years of age[J].J Clin Micro,2004,42(10):4632-4635.
  • [9]Boivin G,De Serres G,Cote S,et al.Human metapneumovirus infections in hospitalized children[J],Emerg Infect Dis,2003,9(6):634-640.
  • [10]Ebihara T,Endo R,Kikuta H,et al.Human metapneumovirus infection in Japanese children[J].J Clin Microbiol,2004,42 (1):126-132.
  • [11]刘恩梅,王莉佳,邓兵,等.重庆地区人类偏肺病毒感染与小儿毛细支气管炎[J].临床儿科杂志,2004,22(9):607-609.
  • [12]曹力,卢竞,钱渊,等.6岁以下儿童急性下呼吸道感染的病毒病原及临床研究[J].中国实用儿科杂志,2004,19(9):528-531.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn