Abstract: Objective To analyze the significance of serum Fractalkine (FKN) level change in acute cerebral infarction.Methods Forty-five acute ischemic stroke patients were enrolled.Double antibody sandwich EUSA was used to determine serum FKN level at 1~3、7、14 and 28 days after onset.Relation between the serum FKN levels and volume and position of cerebral infarction focus.meanwhile the score of 3 months'quality of life were analyzed.Results Serum FKN levels at different time points in cerebral infaretion group were higher than control group(P<0.05).FKN reached peak level 7 days after onset.Serum FKN level was significantly higher in large volume infaretion and cortex and concomitant subcortex than other subtypes.Conclusion FKN could be a serum marker for ischemic inflammatory cerebral injury.Serum FKN level in patients with acute cerebral infarction was related to the volume and location of cerebral infarction focus and prognosis of patients.Serum FKN level was an important index for observation of curative effects and prognosis.