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Research of correlation between heart-type fatty acid binding protein and acute coronary syndrome.
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- Author:
- No author available
- Journal Title:
- CHINA MEDICINE
- Issue:
- 11
- DOI:
- 10.3760/cma.j.issn.1673-4777.2007.11.006
- Key Word:
- 急性冠状动脉综合征;心型脂肪酸结合蛋白;危险分层;独立危险因素
Abstract： 目的 探讨心型脂肪酸结合蛋白(H-FABP)与急性冠状动脉综合征(ACS)早期诊断、危险分层及预后的关系.方法 分别测定90例ACS患者(ACS组)、20例稳定型心绞痛(SAP)患者(SAP组),及30例健康体检者(正常对照组)的血清H-FABP浓度,比较ACS组内H-FABP与肌钙蛋白(CTnT)的变化,比较ACS组中低、中、高危患者的H-FABP浓度的不同,并于4周内观察各组住院期间并发症情况及预后的情况.结果 ACS组发病3h内的患者H-FABP阳性率为40%,CTnT阳性率为10%(P＜0.05);发病6 h内的患者H-FABP阳性率65%,CTn阳性率30%(P＜0.05);所有样本中H-FABP阳性诊断ACS的敏感性是95.7%,CTnT阳性诊断ACS的敏感性是81.5%(P＜0.05).ACS组内低、中、高危及急性心肌梗死患者H-FABP浓度差异具有统计学意义,发生心脏意外事件患者血清H-FABP浓度均高于未发生心脏意外事件患者(P＜0.01).结论 H-FABP的定量测定对ACS患者的早期诊断、危险分层及预后评估具有重要的临床价值.
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