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Effects of Valsartan on patients with subarachnoid hemorrhage.
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- Author:
- No author available
- Journal Title:
- CHINA MEDICINE
- Issue:
- 11
- DOI:
- 10.3760/cma.j.issn.1673-4777.2007.11.002
- Key Word:
- 蛛网膜下腔出血;缬沙坦;脑血管痉挛;降钙素基因相关肽
Abstract： 目的 研究缬沙坦对蛛网膜下腔出血(SAH)患者脑脊液和血浆中内皮素(ET)、降钙素基因相关肽(CGRP)含量的影响和临床疗效观察.方法 62例SAH患者分成缬沙坦组32例和对照组30例,比较2组临床疗效和迟发性脑血管痉挛(CVS)的发病情况并了解脑脊液和血浆内皮素、CGRP含量的改变.结果 缬沙坦组症状缓解较快,CVS发病数较对照组明显减少;1周时缬沙坦组脑脊液、血浆内皮素含量较对照组明显降低,CGRP含量较对照组明显升高;2周时2组脑脊液、血浆内皮素、CGRP含量无统计学意义.结论 缬沙坦能减少SAH患者CVS的发生,可能是通过阻止脑脊液和血浆内皮素含量升高及CGRP含量降低发挥作用.
- [1]刘汝宏.脑脊液置换法治疗蛛网膜下腔出血25例[J].2001,(7).
- [2]吕智尉,李光明,吕有灵,等.脑蛛网膜下腔出血患者血浆中NO和ET的动态观察及其临床意义[J].2001,(4).
- [3]申玉兰,井维春.脑脊液置换治疗蛛网膜下腔出血35例分析[J].2004,(8).
- [4]张峰,李彬,李玉东.缬沙坦对原发性高血压左室肥厚患者血浆内皮素的影响[J].2004,(3).
- [5]Diz DI,Li P,Fukuhara M,etc.Novel angiotensin II AT(1) receptor antagonist irbesartan prevents thromboxane A(2)-induced vasoconstriction in canine coronary arteries and human platelet aggregation.[J].2000,292(1).
- [6]Z, Hlubocká,V, Umnerová,S, Heller,etc.[Is mild essential hypertension without obvious organ complications and risk factors associated with increased levels of circulating markers of endothelial dysfunction? Effect of ACE inhibitor therapy].[J].2002,48(8).
- [7]Christopher, Lan,Debarsi, Das,Andrew, Wloskowicz,etc.Endothelin-1 modulates hemoglobin-mediated signaling in cerebrovascular smooth muscle via RhoA/Rho kinase and protein kinase C.[J].2004,286(1).
- [8]Moon CT,Gajdusek C,London S,etc.Expression of endothelial nitric oxide synthase after exposure to perivascular blood.[J].2001,48(6).
- [9]M, Yanagisawa,H, Kurihara,S, Kimura,etc.A novel potent vasoconstrictor peptide produced by vascular endothelial cells.[J].1988,332(6163).
- [10]Dejam A,Pluta RM,Oldfield EH,etc.Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage.[J].2005,293(12).
- [11]Zubkov AY,Parent AD,Bryan RM Jr,etc.Mechanism of endothelin-1-induced contraction in rabbit basilar artery.[J].2000,31(2).
- [12]Weir, M. R.,Drau, V. J..The Renin-Angiotensin-Aldosterone System: A Specific Target for Hypertension Management[J].1999,12(12).